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the use of a positron emission tomography (PET)-based estradiol challenge examine turned into discovered to be highly predictive of response to endocrine therapy in women with estrogen-receptor (ER)-nice breast cancer.
in the phase 2 look at (NCT02455453), facts from which have been published in Nature Communications, the investigators measured the responses to endocrine therapy with the aid of monitoring the trade in tumor uptake of the progestin analog 21-[18F] fluorofuranylnorprogesterone (FFNP) before and after a 1-day estradiol challenge.
The researchers hypothesized that this brief estradiol problem would boost tumor progesterone receptor degrees simplest in tumors with useful estrogen receptors, thereby allowing the crew to identify which tumors would reply to endocrine therapy.
The examine blanketed 43 postmenopausal women with superior ER-wonderful breast cancer. The median patient age became 60 years. an increase in tumor FFNP uptake became viewed in 28 sufferers with scientific improvement from endocrine therapy, described as no sickness progression within 6 months. These patients had been considered to be responders.
Fifteen women were regarded nonresponders. every of the women have been found to journey disease development inside 6 months of initiating endocrine remedy.
The median percentage alternate in tumor FFNP uptake amongst responders turned into 25.four%; in nonresponders, it changed into –0.7%. These outcomes point out a a hundred% sensitivity and specificity, in response to the researchers.
No opposed or clinically detectable pharmacological consequences had been linked to FFNP administration and there were no huge changes in a must have indications.
“while the effects of this examine are extraordinarily promising, their findings deserve to be Checked
in a multicenter trial earlier than this formula will also be used to e-book ET in scientific follow,” Dehdashti et al concluded.
Disclosures: some of the look at authors disclosed financial relationships with the pharmaceutical business and/or the medical device trade. For a full checklist of disclosures, please confer with the original look at.
Dehdashti F, Wu N, Ma CX, Naughton MJ, Katzenellenbogen JA, Siegel BA. affiliation of PET-based mostly estradiol-problem look at various for breast cancer progesterone receptors with response to endocrine remedy. Nat Commun. 2021;12(1):733. doi:10.1038/s41467-020-20814-9
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