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the use of a positron emission tomography (PET)-primarily based estradiol challenge verify was discovered to be particularly predictive of response to endocrine therapy in ladies with estrogen-receptor (ER)-high quality breast cancer.
within the phase 2 analyze (NCT02455453), data from which have been published in Nature Communications, the investigators measured the responses to endocrine remedy by using monitoring the change in tumor uptake of the progestin analog 21-[18F] fluorofuranylnorprogesterone (FFNP) before and after a 1-day estradiol challenge.
The researchers hypothesized that this short estradiol challenge would boost tumor progesterone receptor degrees only in tumors with useful estrogen receptors, thereby permitting the crew to identify which tumors would reply to endocrine remedy.
The examine included forty three postmenopausal girls with advanced ER-nice breast melanoma. The median patient age was 60 years. a rise in tumor FFNP uptake turned into viewed in 28 patients with scientific benefit from endocrine therapy, described as no sickness progression within 6 months. These patients have been considered to be responders.
Fifteen women have been regarded nonresponders. every of the ladies have been found to journey ailment progression inside 6 months of initiating endocrine remedy.
The median percent alternate in tumor FFNP uptake among responders was 25.four%; in nonresponders, it become –0.7%. These effects point out a one hundred% sensitivity and specificity, according to the researchers.
No hostile or clinically detectable pharmacological results were linked to FFNP administration and there were no colossal alterations in essential signals.
“whereas the outcomes of this analyze are extremely promising, their findings need to be Verified in a multicenter trial earlier than this formula can be used to ebook ET in scientific observe,” Dehdashti et al concluded.
Disclosures: one of the study authors disclosed monetary relationships with the pharmaceutical business and/or the scientific device trade. For a full listing of disclosures, please check with the customary study.
Dehdashti F, Wu N, Ma CX, Naughton MJ, Katzenellenbogen JA, Siegel BA. affiliation of PET-based estradiol-challenge test for breast melanoma progesterone receptors with response to endocrine therapy. Nat Commun. 2021;12(1):733. doi:10.1038/s41467-020-20814-9
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